Inositol, a lesser-known nutrient often grouped with the B vitamins, is gaining attention for its potential medicinal and therapeutic benefits. Found in numerous foods and available as a supplement, inositol plays a crucial role in several important bodily functions, ranging from cell signalling to neurotransmitter regulation.
Read on to know what inositol supplements are, their potential health benefits, common uses, recommended dosage, and possible side effects.
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What Is Inositol?
Inositol referred to as vitamin B8, is a naturally occurring carbohydrate compound similar in structure to glucose. Despite not being classified as a vitamin, inositol is essential for the proper working of cells, particularly in the brain and nervous system. It is a precursor to various signalling molecules and is involved in several important physiological processes, including insulin signalling, lipid metabolism, and neurotransmitter action.
Health Benefits of Inositol Supplements:
Mental Health Support
Inositol has been extensively studied for its proven benefits in managing mood disorders such as depression, anxiety, and panic disorder. It is believed to modulate neurotransmitter pathways in the brain, particularly those involving serotonin, a neurotransmitter known for regulating mood.
Polycystic Ovary Syndrome (PCOS)
Women with PCOS often have insulin resistance, leading to hormonal imbalances and other symptoms like irregular menstrual cycles and infertility. Inositol supplementation has shown promise in improving insulin sensitivity, ovarian function, and menstrual regularity in women with PCOS.
Fertility Enhancement
Inositol supplementation may benefit individuals struggling with infertility, especially those with conditions like PCOS or insulin resistance. Studies suggest that inositol supplementation may improve ovarian function, hormone levels, and egg quality, thus increasing the chances of conception.
Metabolic Health
Inositol plays a role in insulin signalling and glucose metabolism, potentially benefiting people with certain medical conditions like diabetes or metabolic syndrome. Some research indicates that inositol supplementation may promote insulin sensitivity and help keep blood sugar levels under control.
Common Uses of Inositol Supplements
Mood Disorders
Inositol supplements are often used as adjunctive therapy in managing depression, anxiety, and panic disorder. They may be taken alone or alongside conventional treatments such as antidepressant medications.
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PCOS Management
Women with PCOS may benefit from inositol supplementation to improve hormonal balance, ovarian function, and fertility outcomes. It is typically used alongside lifestyle modifications and other treatments for PCOS.
Support for Insulin Resistance
Inositol supplements may be used to improve insulin sensitivity and aid in managing conditions characterized by insulin resistance, such as type 2 diabetes and metabolic syndrome.
Dosage Recommendations:
Dosage recommendations for inositol supplements can vary depending on the targeted health condition. However, typical dosages range from 500 milligrams to 4 grams per day, divided into multiple doses. It's vital to follow the appropriate dosage instructions provided by healthcare professionals or on the supplement packaging to ensure safety and effectiveness.
Potential Side Effects
Inositol supplements are generally considered safe for most people when taken at recommended dosages. However, some individuals may experience mild side effects, including nausea, stomach discomfort, and diarrhoea, especially at higher doses. Additionally, individuals with certain medical conditions, such as bipolar disorder, should use caution when taking inositol supplements, as they may affect mood or interact with medications.
Conclusion:
Inositol supplements offer a range of potential health benefits, from supporting mental health to improving fertility and metabolic function. While more research is needed to understand the extent of these benefits and optimal usage fully, inositol shows promise as a versatile nutrient with various applications in health and wellness. As with any supplement, it's essential to consult a healthcare provider before starting inositol supplementation, especially if you have underlying medical problems or are taking medications.
References:
Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes
James J DiNicolantoniocorresponding author and James H O'Keefe
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896029/
Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
Meysam Zarezadeh,corresponding author 1 , 2 Azadeh Dehghani, 1 , 3 Amir Hossein Faghfouri, 1 , 3 Nima Radkhah, 3 Mohammad Naemi Kermanshahi, 2 Fatemeh Hamedi Kalajahi, 4 Niyaz Mohammadzadeh Honarvar, 4 Zohreh Ghoreishi, 2 Alireza Ostadrahimi, 2 and Mehrangiz Ebrahimi Mamaghanicorresponding author 5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159559/
