The skincare industry is brimming with endless products that promise radiant, glowing skin and it is quite easy to get caught up in the excitement of trying new products and creating the perfect routine. However, not all products are created equal, and some don't play well together. Just as certain ingredients in food can clash and cause discomfort, some skincare products can counteract each other's effectiveness or even lead to irritation when mixed. 

Understanding the chemistry behind your skincare products is essential for achieving healthy, radiant skin without compromising its natural balance. 

In this short read, let us explore the most common skincare combinations that should be avoided and why, helping you navigate the delicate art of product layering and ensuring that each step of your routine enhances, rather than hinders, your skin's health.

Also Read: How To Layer Skincare Products? 8 Right Routine Steps One Should Follow For That Gorgeous Look

What Is Skincare Chemistry and Why It Matters?

Skincare chemistry refers to the science behind the formulation of skincare products. Each product is designed with specific ingredients that interact with your skin to provide benefits. When mixing products, it is essential to understand the chemistry behind these ingredients to avoid adverse reactions, such as irritation, inflammation, or decreased efficacy.

Looking for the best product combinations for your skincare routine? Browse our collection of expert-approved skincare products for radiant skin!

How To Safely Incorporate Skincare Ingredients Into Your Routine?

While some ingredients may not be suitable for mixing, there are ways to incorporate them into your routine without compromising your skin’s health.

Layering Correctly:

  • Use Vitamin C in the morning: Apply it first on clean skin, followed by sunscreen.
  • Retinol in the evening: Since retinol makes your skin more sensitive to the sun, it is best used at night.
  • Niacinamide can be used with almost any product: Apply it after cleansing and before heavier serums or oils.
  • Exfoliants once or twice a week: Don’t over-exfoliate with AHAs or BHAs. Use these acids sparingly.

Also Read: Skincare Chemistry:  Products You Should Never Mix and Match For Radiant Glow And Health

When mixing products, it is essential to understand the chemistry behind these ingredients to avoid adverse reactions, such as irritation, inflammation, or decreased efficacy.

While the skincare world is vast and diverse, there are a few combinations that should be avoided for the sake of your skin’s health and glow. Foray through this infographic and find out a breakdown of the most common no-go pairs.

skincare chemistry


Frequently Asked Questions

Can I mix Vitamin C and retinol?

It is best to use them separately, as they can irritate when combined.

What happens if I mix niacinamide and Vitamin C?

The combination may reduce the effectiveness of both ingredients, leading to less noticeable results.

What is the best time to apply Vitamin C in my routine?

Vitamin C should be applied in the morning, as it helps protect against environmental damage.

(This article is reviewed by Kalyani Krishna, Chief Content Editor)

Author Profile

Soumita Basu:

Soumita Basu holds a Bachelor’s Degree in Pharmacy and is deeply interested in Ayurveda, wellness, and skincare. With years of experience creating evidence-based content, she shares her insights on achieving healthy, glowing skin.

References:

  1. The Science Behind Skincare Ingredients: How They Interact and Affect Your Skin
  2. Retinol and Vitamin C: A Detailed Overview of Skincare Synergy and Conflicts