The Folic Acid Serum Test or the serum folate test, is a blood work designed to measure the levels of folic acid, or vitamin B9, in the bloodstream. Folic acid is a vital vitamin involved in several bodily processes and functions, including DNA synthesis and repair, red blood cell formation, and neural tube development during pregnancy. If you suspect a folate-related concern or fall into one of the high-risk categories, consult with a healthcare provider to determine if the folic acid serum test is appropriate for you.

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Dive into this article to learn more about the purpose of the folic acid serum test, the procedure, and how to interpret the results.

What Is Folic Acid Serum Test?

The Folic Acid Serum Test is a blood test that measures the concentration of folic acid in the bloodstream. Folate is a water-soluble B vitamin found in various foods, and its levels in the body can be indicative of dietary intake, absorption, and overall nutritional status.

(Also Read: Folic Acid And Pregnancy: This Is How Vitamin B9 Can Make Your Pregnancy Better)

Who Needs a Folic Acid Serum Test?

Pregnant Women

Folic acid is a crucial vitamin needed during pregnancy to avert the risk of neural tube defects in the developing foetus. Doctors usually, recommend pregnant women to take folic acid supplements, and the serum test can help monitor and ensure adequate levels.

Individuals with Anaemia

Folate deficiency can contribute to megaloblastic anaemia, characterized by larger-than-normal red blood cells. The test may be recommended for individuals with unexplained anaemia to assess their folate levels.

Malabsorption Conditions

Some of the medical conditions like celiac disease or inflammatory bowel diseases, can affect the absorption of nutrients, including folic acid. Individuals with these conditions may undergo the test to evaluate their folate status.

(Also Read: Vitamin B9: Functions, Food Sources, Deficiencies and Toxicity)

Chronic Diseases

Chronic diseases or conditions that impact folate metabolism, such as liver disease or certain cancers, may necessitate evaluation of folate levels to prevent deficiency.

Alcoholism

Excessive alcohol consumption can lead to folate deficiency. Individuals with a history of alcohol abuse may undergo the test to assess their folic acid levels.

Preparation

Typically, no special preparation is required for the folic acid serum test. However, individuals may be advised not to eat or drink at least 6 hours before going for the test and stop taking any medications as it may interfere with results.

A healthcare professional or phlebotomist will draw a small amount of blood sample from a vein in the arm. This process is relatively quick and involves minimal discomfort. The blood sample collected is then sent to a laboratory for analysis.

Results

The folic acid blood test is interpreted in terms of high and low. A higher value than the normal folic acid range does not result in any problems as it is a water-soluble vitamin and is easily eliminated via the urine.

Normal Range: The normal value of folic acid in the blood ranges between 2.7 and 17.0 nanograms per millilitre.

Low Levels: Indicates potential folate deficiency, anaemia, and poor absorption of vitamins, which may require dietary changes or supplementation.

High Levels: While less common, elevated folate levels can occur, possibly indicating excessive supplementation.

References:

1. Clinical Utility of Folic Acid Testing for Patients with Anemia or Dementia,M. Javed Ashraf, MD, corresponding author1,3 James R. Cook, MD, MPH,1,3 and Michael B. Rothberg, MD, MPH2,3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517884

2. Folic Acid Deficiency Kashif M. Khan; Ishwarlal Jialal

https://www.ncbi.nlm.nih.gov/books/NBK535377

Disclaimer:

The content provided here is for informational purposes only. This blog is not intended to substitute for medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider for any questions or concerns you may have regarding a medical condition. Reliance does not endorse or recommend any specific tests, physicians, procedures, opinions, or other information mentioned on the blog.