INTRODUCTION

XYLOCHEK contains Xylometazoline which belongs to the group of medicines called Nasal decongestants. It is used in adults and in adolescents (aged 12 years or above) to provide relief from nasal congestion. It can also be used to provide relief from unpleasant symptoms of nasal cavity (such as nasal block, itching or discomfort) caused due to sinusitis (inflammation of the sinuses) or allergic rhinitis (an allergic condition)

Always use XYLOCHEK as directed by your physician. It is for intranasal use only. Do not use XYLOCHEK for more than 7 days without consulting your doctor.

Before using XYLOCHEK inform your doctor if you have diabetes, hypertension, glaucoma, hyperthyroidism, or any heart problems. You must also inform your doctor if you have any other problems in nasal tract apart from nasal congestion such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis).

Consult your doctor before using XYLOCHEK if you are pregnant, think you may be pregnant or breastfeeding. The most common side effects of using XYLOCHEK are irritation or burning sensation after application and nasal dryness. Consult your doctor if any of these side effect worsens.

USES OF XYLOCHEK

It is used in adults and in adolescents (aged 12 years or above) to provide relief from:

Nasal congestion (blocked nose)
Sinusitis (inflammation of the tissues lining the sinuses)
Allergic rhinitis (nasal congestion caused due to allergic reactions)

HOW XYLOCHEK WORKS

XYLOCHEK opens and clears the nasal passages. It works by narrowing down the blood vessels supplying the nasal passage. This helps swollen blood vessels of the nasal tract to return to its normal size which allows the air to pass through the nostrils more freely. It also reduces the excessive nasal secretions and provides temporary relief from nasal inflammation, swelling and discomfort.

DIRECTIONS FOR USE

Always use XYLOCHEK as directed by your physician. It is for intranasal use only.

For Nasal Drops: Gently instill few drops of this medicine into each nostril. Clean the dropper after application.

For Nasal Spray: Insert the spray nozzle inside the affected nostril. Press the pump to release the spray and sniff at the same time. Repeat the same to the other nostril if required. Clean the nozzle after application.

To avoid possible spread of infection, this pack should only be used by a single person. Do not use XYLOCHEK for more than 7 days without consulting your doctor. Discard the unused portion after 28 days of opening it.

SIDE EFFECTS OF XYLOCHEK

COMMON

dry nose
nose discomfort
headache
nausea
irritation or burning sensation after application

UNCOMMON

nosebleeds

RARE

Stop using XYLOCHEK and contact your doctor immediately if you experience any of the following side effects:

severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
severe itching of the skin, with red rash or raised spots on the skin

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea

Take XYLOCHEK with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor before using XYLOCHEK if you are pregnant or think you may be pregnant.

BREASTFEEDING

Consult your doctor before using XYLOCHEK if you are breastfeeding.

DRIVING AND USING MACHINES

Do not drive or operate any tools or machines if your ability is affected by XYLOCHEK.

ALLERGY

Do not use XYLOCHEK if you are allergic to Xylometazoline or to any other ingredients of this medicine.

HEART DISEASE

XYLOCHEK should be used with caution in patients with heart disease (such as hypertension, prolonged QT syndrome). Therefore, consult your doctor before using it.

OTHERS

XYLOCHEK is not recommended for use if you:

have had a recent neurosurgery
have narrow angle glaucoma (increased pressure within the eyes)
have any problems in nasal tract such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis)
have an enlarged prostate gland
have phaeochromocytoma (a rare tumor of the adrenal glands)

Before using XYLOCHEK, inform your doctor if you:

have diabetes
have hyperthyroidism (overactive thyroid gland)

Use in pediatrics:

XYLOCHEK can be used in children and adolescents aged 12 years or above. You must consult your doctor before using XYLOCHEK if your child is aged 6 years or above. It is not recommended for use in children aged below 6 years. Therefore, consult your doctor for advice before administration.

Use in geriatrics:

XYLOCHEK should be used with caution in elderly patients. Therefore, consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before using XYLOCHEK, inform your doctor if you are taking any of the following medicines:

antidepressants (used to manage depression) such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc
medicines used to control blood pressure such as alpha blockers (Ex. prazosin, terazocin) or beta blockers (Ex. propranolol, atenolol)

timolol, betaxolol (used to manage glaucoma in the eye)

Overdosage:

If you or anyone else accidentally applied too much of XYLOCHEK, consult your doctor immediately.

SYNOPSIS

Drug	:	Xylometazoline
Pharmacological Category	:	Alpha-Adrenergic Agonist
Therapeutic Indication	:	Nasal congestion, sinusitis, perinnial allergic rhinitis
Dosage Forms	:	Nasal drops, Nasal spray

MORE INFORMATION

Keep XYLOCHEK out of reach to children
Store XYLOCHEK at room temperature

FAQs ABOUT XYLOCHEK

What is the use of XYLOCHEK?

XYLOCHEK is used to provide relief from nasal congestion. It can also be used to provide relief from unpleasant symptoms of nasal cavity (such as nasal block, itching or discomfort) caused due to sinusitis or allergic rhinitis.

Can XYLOCHEK be used every day?

Use XYLOCHEK for the duration prescribed by your doctor. Do not use XYLOCHEK for more than 7 days without consulting your doctor. Prolonged use of XYLOCHEK may worsen your condition.

Is it safe to use XYLOCHEK?

Yes. XYLOCHEK is one of the safe and well tolerated medicine. It does not cause any harmful side effects. It may cause local irritation or burning sensation after application which is quite normal and disappears after few minutes.

What are the side effects of XYLOCHEK?

The most common side effects of using XYLOCHEK are irritation or burning sensation after application and nasal dryness. Consult your doctor if they bother you.

Can XYLOCHEK be used in children?

Is XYLOCHEK an antihistamine?

XYLOCHEK is a sympathomimetic agonist. It directly acts on the alpha-adrenergic receptors of the blood vessels supplying the nasal tract and narrows them down. This reduces swelling of the nasal tract and allows the air to pass through the nostrils more freely.

How long it takes for XYLOCHEK to work?

XYLOCHEK may show its therapeutic effect after 5 to 10 minutes of application. It works by narrowing of blood vessels in the affected lining of the nose and helps to provide relief from congestion.

Can XYLOCHEK cause rebound congestion?

Yes, XYLOCHEK may cause rebound congestion (worsening of congestion due to nasal decongestant sprays) if you use for more than the duration recommended by your doctor.

REFERENCES

1. K.D. Tripathi. Adrenergic System and Drugs. Essential of Medical Pharmacology. 7th Edition. Page – 136.

2. Xylometazoline. ScienceDirect.com. [Accessed on 30th August 2022]. https://www.sciencedirect.com/topics/medicine-and-dentistry/xylometazoline#:~:text=Clinical%20Pharmacology%3A,Therapeutic%20Effect%3A%20Decreased%20nasal%20congestion.

3. Ronald Eccles, Kaj Martensson and Shirley C. Chen. Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold. Taylor Francis Online. January 2010. [Accessed on 30th August 2022]. https://www.tandfonline.com/doi/abs/10.1185/03007991003648015?journalCode=icmo20

4. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 30th August 2022]. https://www.medicines.org.uk/emc/files/pil.5984.pdf

5. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 30th August 2022]. https://www.medicines.org.uk/emc/files/pil.1412.pdf