INTRODUCTION ABOUT SITASON D 100/10 TABLET

SITASON D 100/10 TABLET is used to manage type II diabetes mellitus which is inadequately controlled on metformin monotherapy. It is a combination of Dapagliflozin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It effectively controls blood sugar levels where dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

SITASON D 100/10 TABLET is not recommended for use in patients having severe kidney problems or those on dialysis. Before taking the medicine, inform your doctor if you have inflammation of the pancreas, gallstones, alcohol dependence, or very high levels of triglycerides in the blood or any heart, kidney or liver problems. It should be used in pregnant women only if considered clearly necessary. It should be used with caution in breastfeeding women. Safety and effectiveness of SITASON D 100/10 TABLET in children and adolescents (under 18 years of age) have not been established.

It is important to stay on the diet and exercise recommended by your doctor while taking SITASON D 100/10 TABLET as it can help the body use its blood sugar better. The most common side effects are headache, flatulence and constipation. Consult your doctor if any of the side effects worsen or persist for a longer period of time.

USES OF SITASON D 100/10 TABLET

Used to manage type II diabetes mellitus (which is inadequately controlled on metformin monotherapy)

HOW SITASON D 100/10 TABLET WORKS

SITASON D 100/10 TABLET effectively controls blood sugar levels where Dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

DIRECTIONS FOR USE

Take SITASON D 100/10 TABLET as advised by your physician
Swallow the medicine with a glass of water. Do not crush or chew the medicine
It can be taken with or without food
Your doctor will decide the correct dose and duration of SITASON D 100/10 TABLET therapy depending on your age, body weight and disease condition.

SIDE EFFECTS OF SITASON D 100/10 TABLET

Common Side Effects of SITASON D 100/10 TABLET:

flatulence, constipation, stomach pain, diarrhea
swelling of hands or legs
headache, dizziness
stuffy or runny nose, sore throat
passing urine more often
dry mouth

Stop taking SITASON D 100/10 TABLET and contact your physician immediately if you experience any of the following side effects:

inflamed pancreas (severe and persistent stomach pain that might reach through the back with or without nausea and vomiting)
serious allergic reaction (rash, hives, blisters on the skin or peeling skin and swelling of the lips, tongue, face and throat that may cause difficulty in breathing or swallowing)
diabetic ketoacidosis (increased levels of ketone bodies in urine or blood, nausea or vomiting, stomach ache, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breathe, a sweet or metallic taste in the mouth or a different odor in urine or sweat, rapid weight loss)
urinary tract infection (fever, chills, burning sensation when passing urine, pain in the back or side, blood in urine)
low blood sugar levels (shaking, sweating, feeling very anxious, fast heartbeat, feeling hungry, headache, change in vision, and a change in mood or feeling confused)

No dose adjustment is required for elderly patients.

OTHERS

SITASON D 100/10 TABLET is not recommended for use if you have:

type I diabetes mellitus
diabetic ketoacidosis

Before taking SITASON D 100/10 TABLET inform your doctor if you:

have inflammation of the pancreas
have gallstones
have very high levels of triglycerides in the blood
are fasting
are dehydrated

INTERACTIONS

A. Drug-Drug interactions:

Before taking SITASON D 100/10 TABLET, inform your doctor if you are taking any of the following medicines:

Anti-fungal (Ex. ketoconazole, itraconazole)
Anti-viral agents (Ex. Ritonavir)
Antibiotics (Ex. Clarithromycin)
Immunosuppressants (Ex. Ciclosporin)
Cardiac glycosides (Ex. Digoxin)
Diuretics (Ex. hydrochlorothiazide, furosemide)
Anti-diabetics (Ex. metformin, insulin, glimepiride)

Overdosage:

If you or anyone else accidentally takes too much of SITASON D 100/10 TABLET, consult your doctor or visit a nearby hospital immediately.

SYNOPSIS

Drug	:	Dapagliflozin, Sitagliptin
Pharmacological Category	:	Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor, Dipeptidyl Peptidase 4 (DPP-4) inhibitor
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

MORE INFORMATION

Disease Description:

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It may be due to impaired insulin secretion, resistance to peripheral actions of insulin, or both. The symptoms of diabetes mellitus are related to high blood glucose levels. They include excessive urination, thirst and hunger, weight loss, increased susceptibility to infections, especially yeast or fungal infections.

FAQs ABOUT SITASON D 100/10 TABLET

Q: What is SITASON D 100/10 TABLET and why it is prescribed?

A: SITASON D 100/10 TABLET is a combination of Dapagliflozin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to manage type II diabetes mellitus which is inadequately controlled on metformin monotherapy.

Q: Does SITASON D 100/10 TABLET cause weight loss?

A: Yes, SITASON D 100/10 TABLET may cause weight loss in some individuals. To avoid weight loss, follow a healthy diet and regular physical activity as advised by your physician.

Q: Can SITASON D 100/10 TABLET be taken along with insulin?

A: Taking SITASON D 100/10 TABLET along with insulin might increase the chance of hypoglycemia.

Q: How does SITASON D 100/10 TABLET work?

A: SITASON D 100/10 TABLET effectively controls blood sugar levels where dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

Q: Is SITASON D 100/10 TABLET safe to use in patients with kidney problems?

A: SITASON D 100/10 TABLET can be used with caution in patients who had or have any kidney problems. Your doctor may monitor your kidney function test before and during management with this medicine to manage the risk of any unusual effects.

REFERENCES

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 297 & 301.

2. Serge A. Jabbour; Elise Hardy; Jennifer Sugg; Shamik Parikh. Dapagliflozin Is Effective as Add-on Therapy to Sitagliptin With or Without Metformin: A 24-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study. Journal of Diabetes care. American Diabetes Association. February 2014. [Accessed on 27th November 2023] click here

3. Annaswamy Raji, Zhi Jin Xu, Raymond L. H. Lam, Edward A.O’Neill, Keith D. Kaufman, Samuel S. Engel. Efficacy and Safety of Sitagliptin Compared with Dapagliflozin in People ≥65 Years Old with Type 2 Diabetes and Mild Renal Insufficiency. SpringerLink. August 2020. [Accessed on 27th November 2023] click here

4. Torrent Pharmaceuticals Ltd. Sitaxa D/ Sitalix D/Glucreta S (Dapagliflozin + Sitagliptin). [Revised in July 2022] [Accessed on 27th November 2023] click here

5. Cipla Ltd. Exemed Pharmaceuticals. Darasach S (Dapagliflozin + Sitagliptin). Ciplamed. [Revised in September 2022] [Accessed on 27th November 2023] click here

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AUTHOR DETAILS

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 10 Oct 2024 | 04:58 PM(IST)