INTRODUCTION ABOUT PILORUTE CREAM

PILORUTE CREAM is a combination of Calcium Dobesilate, Hydrocortisone Acetate, Lignocaine, Phenylephrine, Troxerutin and Zinc Oxide which belong to the group of medicines called Anti-haemorrhoids. It is indicated for pain and bleeding associated with anal fissures (a small tear in the lining of anus), haemorrhoids or piles (lumps inside or around your anus), after haemorrhoids removal surgery and in management of recurrence of piles following surgery.

PILORUTE CREAM is also used to manage proctitis (inflammation of lining of rectum) and painful evacuation. PILORUTE CREAM is not recommended for use if you have tuberculous or fungal lesions or skin vaccinia (viral infection), chicken pox and acute herpes simplex infection. Consult with your doctor before using it.

PILORUTE CREAM should be used with caution in patients with lung, liver and heart problems. PILORUTE CREAM should be used during pregnancy only if clearly necessary. It should be used with caution in breastfeeding women. Consult your doctor before using it.

PILORUTE CREAM is not recommended for use in children under 12 years of age. It should be used with caution in elderly patients. The most common side effects of using PILORUTE CREAM are burning, irritation, redness, itchiness at the application site. Consult your doctor if any of the symptoms worsen.

USES OF PILORUTE CREAM

PILORUTE CREAM is used in following conditions:

• anal fissures
• haemorrhoids or piles
• after haemorrhoids removal surgery
• prevention of recurrence of piles following surgery
• proctitis
• painful evacuation

HOW PILORUTE CREAM WORKS

Troxerutin and Calcium Dobesilate are vasoprotective medicine that works by strengthening the blood vessels at the affected site and also promote fast healing. Lignocaine is a local anaesthetic and Hydrocortisone belongs to the class of steroids together works by decreasing itching, inflammation, redness and swelling. Phenylephrine belongs to the group of decongestants that works by shrinking the swollen blood vessels and eventually relieving site irritation and itching in piles. Zinc oxide is an astringent, which helps to reduce painful swelling and shrink the haemorrhoids. It also protects the skin on the anus from infections. Thus PILORUTE CREAM helps to shrink pile mass and heals anal fissure effectively.

DIRECTIONS FOR USE

Apply PILORUTE CREAM as advised by your physician. It is for topical use only. Wash your hands before and after use. Apply a thin layer of this medicine over the affected area with the help of an applicator or as directed by physician. Avoid the medicine in contact with your eyes, ears, nose or mouth.

SIDE EFFECTS OF PILORUTE CREAM

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

PILORUTE CREAM should be used during pregnancy only if clearly necessary. Consult your doctor before using it.

BREASTFEEDING

Use with Caution

PILORUTE CREAM should be used with caution in breastfeeding women. Consult your doctor before using it.

LIVER

Use with Caution

PILORUTE CREAM should be used with caution in patients with liver problems. Consult with your doctor before using it.

ALLERGY

Contraindicated

Do not use PILORUTE CREAM if you are allergic to Calcium Dobesilate, Hydrocortisone Acetate, Lignocaine, Phenylephrine, Troxerutin, Zinc Oxide or any other ingredient of this medicine.

HEART DISEASE

Use with Caution

PILORUTE CREAM should be used with caution in patients having heart problems. Consult with your doctor before using it.

INTERACTIONS

A. Drug-Drug Interactions:

Before using PILORUTE CREAM, inform your doctor if you are using any of the following medicine:

• medicine used to manage chest pain, high blood pressure (Ex. nitroglycerin, nitroprusside, nitric oxide, nitrous oxide)
• anaesthetics (medicines used to produce temporary loss of consciousness (Ex. benzocaine, lidocaine, bupivacaine, mepivacaine)
• medicine used for cancer (Ex. cyclophosphamide, flutamide, rasburicase, ifosfamide, hydroxyurea)
• antibiotics (medicine used to manage infections) (Ex. dapsone, sulfonamides, nitrofurantoin, para-aminosalicylic acid)
• medicine used to manage malaria (Ex. quinine, chloroquine, primaquine)
• medicine used to manage fits (Ex. phenytoin, sodium valproate, phenobarbital)
• acetaminophen (used to manage pain and fever)
• metoclopramide (used to manage nausea and vomiting)
• sulfasalazine (used to manage ulcerative colitis and Chron’s disease)
• oral laxatives (used to manage constipation) (Ex. lactulose)
• antiarrhythmics (used to manage irregular heartbeats) (Ex. quinidine)

Overdosage:

If you or anyone else accidentally ingested or used too much of PILORUTE CREAM, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep PILORUTE CREAM out of reach of children
• Store PILORUTE CREAM below 25°C

FAQs ABOUT PILORUTE CREAM

Q: How often can I use PILORUTE CREAM?

A: Use PILORUTE CREAM as advised by your physician. Apply in the affected area 3 times a day or as directed by the physician. Consult your doctor if symptoms persist.

Q: What lifestyle modifications have to be taken while using PILORUTE CREAM?

A: Take bath with warm water while using this medicine. This will soothe the area and will also aid in pain. Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals. Drink at least 6-8 glasses of water daily and exercise regularly to maintain healthy bowel movement.

Q: How to use PILORUTE CREAM?

A: Apply PILORUTE CREAM as advised by your physician. It is for topical use only. Wash your hands before and after use. Apply a thin layer of this medicine over the affected area with the help of an applicator or as directed by physician.

Q: Who should not use PILORUTE CREAM?

A: PILORUTE CREAM is not recommended for use if you have tuberculous or fungal lesions or skin vaccinia (viral infection), varicella (chicken pox) and acute herpes simplex infection. Consult your doctor before using it.

Q: Can I stop using PILORUTE CREAM when my symptoms are cleared or relieved?

A: No, do not stop using PILORUTE CREAM and complete the full course of management. Your symptoms may improve before your condition is completely cured. Please consult your doctor before stopping it. Otherwise your symptoms may return.

Q: Will PILORUTE CREAM be more effective if taken more than prescribed?

A: No, a higher than the recommended dosage of PILORUTE CREAM will not be more effective. Moreover, it can result in too much medicine being absorbed into the body and cause unwanted side effects. If you are experienced any increased severity of your symptoms, please consult your doctor for re-evaluation.

REFERENCES

1. K.D. Tripathi. Drugs Acting on Skin and Mucous Membranes, Local Anaesthetics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 895, 887, 360.

2. Bethesda (MD). Calcium Dobesilate. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Calcium%20Dobesilate

3. Bethesda (MD). Hydrocortisone. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Hydrocortisone

4. Bethesda (MD). Lignocaine. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Lignocaine

5. Bethesda (MD). Zinc Oxide. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Zinc%20Oxide

6. Bethesda (MD). Troxerutin. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Troxerutin

7. Bethesda (MD). Phenylephrine. NIH. National Library of Medicine, National Center for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Phenylephrine

8. The Boots Company. Electronic Medicines Compendium (EMC). [Revised in July 2016] [Accessed on 30th August 2022] https://www.medicines.org.uk/emc/files/pil.6730.pdf

9. Lidocaine and Hydrocortisone Cream. Daily Med: National Library of Medicine: National Institute of Health. [Revised in February 2022] [Accessed on 30th August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5c57a310-8d46-4862-bf2a-a7e4fd5bee57

10. Hydrocortisone Ointment. Daily Med: National Library of Medicine: National Institute of Health. [Revised in January 2022] [Accessed on 30th August 2022] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=7ba59aa6-b828-4048-bf86-90c90d9894a0&type=pdf

11. Lidocaine Ointment. Daily Med: National Library of Medicine: National Institute of Health. [Revised in May 2018] [Accessed on 30th August 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=12639881-632d-445d-9ff5-b84567f49179

12. Pilogud cream (Calcium Dobesilate + Hydrocortisone Acetate + Lignocaine + Phenylephrine + Troxerutin + Zinc Oxide). Scot Derma Private Limited. [Accessed on 30th August 2022] https://www.scotderma.com/products/pilogud

13. Pilogo Plus cream (Calcium Dobesilate + Hydrocortisone Acetate + Lignocaine + Phenylephrine + Troxerutin + Zinc Oxide). Leeford Healthcare Ltd. [Accessed on 30th August 2022] https://www.leeford.in/product/1291/pilogo-plus

14. Piledac Plus Ointment (Calcium Dobesilate + Hydrocortisone Acetate + Lignocaine + Phenylephrine + Troxerutin + Zinc Oxide). Innovative Pharmaceuticals. [Accessed on 30th August 2022] https://www.innovativepharma.in/product/piledac-plus-ointment/

15. Dobitex Cream (Calcium Dobesilate + Hydrocortisone Acetate + Lignocaine + Phenylephrine + Troxerutin + Zinc Oxide). Texas Pharmaceuticals Pvt Ltd. [Accessed on 30th August 2022] https://www.texasusa.in/product/dobitex/

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 06 Feb 2023 | 01:07 PM(IST)