INTRODUCTION ABOUT MISOPT EYE DROPS
MISOPT EYE DROPS is a combination of Dorzolamide and Timolol which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It is used to manage increased pressure in the eye caused due to glaucoma or ocular hypertension. It is typically used in patients who have not responded adequately to therapy with beta-blockers (Ex. timolol) alone.
MISOPT EYE DROPS is for ophthalmic use only. Instil a few drops of the medicine into the affected eye(s). Do not touch the tip of the dropper with your eye or other body surfaces to avoid contamination. If you wear soft contact lenses, remove the lens before applying MISOPT EYE DROPS and wait for at least 15 minutes before reinsertion.
Before using MISOPT EYE DROPS inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have or previously had any breathing problems, asthma, COPD, diabetes, thyroid problems, Raynaud’s disease or any other eye problems apart from glaucoma (such as eye infections or eye surgery) as a precaution.
Do not use MISOPT EYE DROPS without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of using MISOPT EYE DROPS are burning or stinging of eyes, eye redness and itching, blurred vision, bitter taste and headache. Consult your doctor if any of these side effects bothers you.
USES OF MISOPT EYE DROPS
- Manage glaucoma/ocular hypertension
HOW MISOPT EYE DROPS WORKS
MISOPT EYE DROPS reduces intraocular pressure by decreasing the production of aqueous humour (a type of lubricating eye fluid) in the eye. As a result, it reduces strain on the eyes and provides relief from unpleasant symptoms of ocular hypertension (such as eye pain, headache, or blurred vision).
DIRECTIONS FOR USE
Use MISOPT EYE DROPS as advised by your physician. It is for ophthalmic use only. Wash your hands before and after application. Tilt your head slightly and gently pull the lower eyelid downwards.
Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination.
Apply applying MISOPT EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying MISOPT EYE DROPS and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon the severity of the disease condition. Do not stop using MISOPT EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again.
SIDE EFFECTS OF MISOPT EYE DROPS
COMMON
Use MISOPT EYE DROPS as advised by your physician. It is for ophthalmic use only. Wash your hands before and after application. Tilt your head slightly and gently pull the lower eyelid downwards.
Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination.
Apply applying MISOPT EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying MISOPT EYE DROPS and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon the severity of the disease condition. Do not stop using MISOPT EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again.
UNCOMMON
- dizziness
- depression
- poor eyesight
- slow heartbeat, fainting, difficulty breathing
- kidney stones
RARE
- tingling or numbness of the hands or feet
- lack of sleep, nightmares, memory loss
- increased muscle pain or cramps
- decreased sex drive
- dry mouth, diarrhoea
- hair loss, skin rash
- Peyronie’s disease (which may cause a curvature of the penis)
Stop using MISOPT EYE DROPS and contact your immediately if you experience any of the following side effects:
- severe eye irritation, inflammation or redness, blurred vision and swelling of eyelids
- severe allergic reactions (such as skin rash, swelling of the eye, eyelids, face, lips, tongue, hands or throat leading to difficulty in breathing)
- blistering and peeling of the skin
- coughing, wheezing, abnormal breathing or abnormal pauses in breathing (apnoea)
HOW TO MANAGE SIDE EFFECTS
Burning or stinging of eyes:
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops or television. Wear protective eyeglasses while going outdoors.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Blurred vision:
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
WARNING & PRECAUTIONS
PREGNANCY
MISOPT EYE DROPS is generally not recommended for use in pregnant women. Therefore, consult your doctor for advice before using it.
BREASTFEEDING
MISOPT EYE DROPS is generally not recommended for use in breastfeeding women. Therefore, consult your doctor for advice before using it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience dizziness or blurred vision after using MISOPT EYE DROPS.
KIDNEY
MISOPT EYE DROPS is not recommended for use in patients with severe kidney diseases or a previous history of kidney stones. It should be used with caution in patients with other minor kidney problems. Therefore, consult your doctor before using it.
LIVER
MISOPT EYE DROPS should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.
ALLERGY
Do not use MISOPT EYE DROPS if you are allergic to Dorzolamide, Timolol or to any other beta-blockers (Ex. labetalol).
LUNGS
MISOPT EYE DROPS is not recommended for use in patients who currently have or previously had any lung problems such as asthma or COPD. It should be used with caution in patients with breathing difficulties. Therefore, consult your doctor before using it.
HEART DISEASE
MISOPT EYE DROPS is not recommended for use in patients with heart problems (such as slow or irregular heartbeat or cardiogenic shock). It should be used with caution in patients with coronary artery disease. Therefore, consult your doctor before using it.
OTHERS
Before using MISOPT EYE DROPS, inform your doctor if you:
- had any surgery in your eyes
- have any other eye problems apart from glaucoma (such as eye infection)
- have low blood pressure
- have Raynaud’s disease (poor blood circulation to hands and feet)
- have diabetes
- have overactivity of the thyroid gland
- wear soft contact lenses
- have any surgery in the upcoming days
Use in pediatrics:
MISOPT EYE DROPS should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before using it.
Use in geriatrics:
MISOPT EYE DROPS should be used with caution in elderly patients. Therefore, consult your doctor before using it.
INTERACTIONS
A. Drug-Drug interactions –
Before using MISOPT EYE DROPS, inform your doctor if you are taking any of the following medicines such as:
- other carbonic anhydrase inhibitors (used to manage glaucoma) Ex. acetazolamide and brinzolamide
- sulphonamides (used to manage bacterial infections) Ex. sulfamethoxazole, sulfasalazine
- medicines used to manage heart problems (such as nifedipine, verapamil or diltiazem)
- digoxin, quinidine (a medicine used to manage irregular heartbeat)
- plant extracts used for hypertension (such as rauwolfia)
- adrenaline (a medicines used to manage hypersensitivity reactions)
- clonidine (a medicine used to manage high blood pressure)
- other beta-blockers (used to manage hypertension or glaucoma) such as pindolol, labetalol, propranolol, atenolol etc.
- medicines used for depression (such as fluoxetine and paroxetine)
- medicines used to manage diabetes (such as metformin, insulin)
- medicines used for pain relief (such as morphine)
Overdosage:
If you or anyone else accidentally used more MISOPT EYE DROPS, rinse your eye with warm water. If still irritation persists, consult your doctor. If you or anyone else accidentally swallowed this medicine, contact your doctor or visit the nearby hospital. Symptoms of overdosage might include headache, dizziness, difficulty in breathing, slow heart rate and chest pain.
SYNOPSIS
| Drug | : | Dorzolamide, Timolol |
| Pharmacological Category | : | Carbonic anhydrase inhibitors, Beta-blockers |
| Therapeutic Indication | : | Glaucoma, Ocular hypertension |
| Dosage Forms | : | Eye drops, Ophthalmic suspension |
MORE INFORMATION
- Keep MISOPT EYE DROPS out of reach of children
- Store MISOPT EYE DROPS at room temperature
FAQs ABOUT MISOPT EYE DROPS
Can the use of MISOPT EYE DROPS cause blurred vision?
Yes. MISOPT EYE DROPS may cause blurred vision after application. If your vision becomes blurred, close your eyes for some time and rest. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blurred. Consult your doctor if you experience blurred vision for a prolonged period.
Is it normal to experience headaches after using MISOPT EYE DROPS?
Yes. The use of MISOPT EYE DROPS may cause headaches in some individuals. If you experience a headache, rest and relax. Applying a pain-relieving balm on your forehead can be beneficial. Do not stress yourself too much. Avoid consuming excessive alcohol. Consult your doctor if your headache worsens.
Can I use other eye medicines while using MISOPT EYE DROPS?
Yes. You can use other eye medicines while undergoing therapy with MISOPT EYE DROPS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.
Who should avoid using MISOPT EYE DROPS?
MISOPT EYE DROPS should be avoided in patients with severe kidney or heart problems. It should be used with caution in patients with liver problems or other problems in the eye such as eye infection or eye surgery. It is also not suitable for use in pregnant or breastfeeding women. Patients aged below 18 years must consult your doctor before using MISOPT EYE DROPS.
How to use MISOPT EYE DROPS?
Use MISOPT EYE DROPS as advised by your physician. It is for ophthalmic use only. Instil a few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. If you wear soft contact lenses, remove the lens before applying MISOPT EYE DROPS and wait for at least 15 minutes before reinsertion.
What is the use of MISOPT EYE DROPS?
MISOPT EYE DROPS is a prescription medicine used to manage increased pressure within the eyes. It is typically used in patients who have not responded adequately to therapy with beta-blockers (Ex. timolol) alone.
How long does it take for [GBNKRYWORD] to work?
It may take about 1 to 4 weeks for MISOPT EYE DROPS to show the results. Therefore, continue to use MISOPT EYE DROPS as prescribed by your physician.
What are the side effects of MISOPT EYE DROPS?
The most common side effects of using MISOPT EYE DROPS are burning or stinging of eyes, eye redness and itching, blurred vision, bitter taste and headache. Consult your doctor if any of these side effect bothers you.
Can I use MISOPT EYE DROPS while wearing contact lenses?
If you wear soft contact lenses, remove the lens before applying MISOPT EYE DROPS and wait for at least 15 minutes before reinsertion. This is because MISOPT EYE DROPS contains preservatives which may interact with your contact lens and make your lens to discolour.
Can I stop using MISOPT EYE DROPS without consulting my doctor?
Do not stop using MISOPT EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again. If you think that you are feeling better or if you wish to stop using MISOPT EYE DROPS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the dose.
Is MISOPT EYE DROPS safe for pregnant and breastfeeding women?
MISOPT EYE DROPS is generally not recommended for use in pregnant women or breastfeeding women. Therefore, consult your doctor before using it.
Can I drive or ride a bike after using MISOPT EYE DROPS?
Do not drive if you feel dizzy or experience blurred vision after using MISOPT EYE DROPS. It also affects the ability to perform tasks that need alertness or coordination, so be cautious while driving.
What if I miss a dose of MISOPT EYE DROPS?
If you missed a dose of MISOPT EYE DROPS, apply it as soon as you remember. However, if it is time for the next dose, skip the missed dose and apply the regular dose. Do not apply a double dose to compensate for the missed dose.
REFERENCES
1. KD. Tripathi. Antiadrenergic drugs and Drugs for Glaucoma. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 148, 153 & 155.
2. Mark R Lesk, Theodoro Koulis, Fotini Sampalis, John S Sampalis, Natacha R Bastien. Effectiveness and safety of dorzolamide-timolol alone or combined with latanoprost in open-angle glaucoma or ocular hypertension. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. April 2008. [Accessed on 9th December 2022]. https://pubmed.ncbi.nlm.nih.gov/18364402/
3. Aspire Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2020]. [Accessed on 9th December 2022]. https://www.medicines.org.uk/emc/product/9889/pil
4. Aspire Pharma Limited. Electronic Medicines Compendium (EMC). [Revised in January 2020] [Accessed on 9th December 2022]. https://www.medicines.org.uk/emc/files/pil.10101.pdf
5. FDC International Ltd. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 9th December 2022]. https://www.medicines.org.uk/emc/files/pil.4053.pdf
6. Cipla Ltd. Dorzox T Eye drops (Dorzolamide Hydrochloride2%+Timolol maleate 0.5%). Ciplamed.com. [Revised in September 2018] [Accessed on 9th December 2022]. https://www.ciplamed.com/content/dorzox-t-eye-drops
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