INTRODUCTION ABOUT HEPAMERZ GRANULES
HEPAMERZ GRANULES contains L-ornithine-L-aspartate, which belongs to the group of medicines called Hepatoprotective agents. It is used in the management of concomitant diseases and complications caused by deterioration of liver detoxification function, with symptoms of latent or severe hepatic encephalopathy and consciousness disorders such as precoma or coma.
L-ornithine-l-aspartate is made up of two amino acids called ornithine and aspartic acid. Both l-ornithine and l-aspartic acid ensure hepatoprotective effects by decreasing the toxic load on the liver and by providing metabolic support for hepatic cells. Before taking this medicine, inform your doctor if you have severe liver disease, because your doctor might adjust the dose on an individual basis to avoid nausea and vomiting.
This medicine is well tolerated with minimal side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor. Do not take this medicine if you have severe renal impairment, diabetes, or fructose intolerance. Ask your doctor for advice. If a high dose of this medicine is used, it is important to monitor the levels of urea both in the serum and urine to avoid toxicity. Ask your doctor for advice before taking this medicine if you are pregnant or breastfeeding.
USES OF HEPAMERZ GRANULES
- Restores normal liver function
- Manages concomitant diseases caused by deterioration of liver function
- Manages symptoms of latent or severe hepatic encephalopathy
- Manages consciousness disorders such as precoma or coma
HOW HEPAMERZ GRANULES WORKS
L-ornithine converts toxic ammonia into non-toxic urea, which is eliminated via the kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-aspartate is an important component of the citric acid cycle, which liberates energy in the form of ATP, which helps in the regeneration of damaged liver cells.
DIRECTIONS FOR USE
Always take this medicine as directed by your physician. Dissolve the contents of 1-2 sachets in a large amount of fluid (Ex. in a glass of water or juice) and consume orally, 3 times a day during or after meals. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF HEPAMERZ GRANULES
HEPAMERZ GRANULES is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionHEPAMERZ GRANULES should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
Use with CautionHEPAMERZ GRANULES should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if your ability is affected by this medicine.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsen liver damage.
KIDNEY
ContraindicatedDo not take HEPAMERZ GRANULES if you suffer from renal insufficiency (severely impaired kidney function). Consult your doctor for advice.
LIVER
Monitoring requiredHEPAMERZ GRANULES should be taken with caution in patients with severe liver disease. Consult your doctor for advice. Dose adjustments have to be made on an individual basis to avoid nausea and vomiting.
ALLERGY
ContraindicatedDo not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.
INTERACTIONS
Do not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.
SYNOPSIS
| Drug | : | L-ornithine-L-aspartate |
| Pharmacological Category | : | Hepatoprotective agent |
| Therapeutic Indication | : | Liver Disease, Hepatic Encephalopathy, Hyperammonemia |
| Dosage Forms | : | Tablet, Granules, Infusion, Syrup |
MORE INFORMATION
STORAGE
- Keep HEPAMERZ GRANULES out of the reach of children
- Store below 20-25°C
FAQs ABOUT HEPAMERZ GRANULES
Q: Can we mix HEPAMERZ GRANULES with juice and consume?
A: Yes. You can mix the contents of the sachet in a glass of water or juice and consume orally, 3 times a day during or after meals.
Q: Can HEPAMERZ GRANULES be taken by pregnant women?
A: This medicine should be used with caution in pregnant women. Consult your doctor before taking it.
Q: Can I consume alcohol while taking HEPAMERZ GRANULES?
A: No. Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsen liver damage.
Q: What is HEPAMERZ GRANULES used for?
A: HEPAMERZ GRANULES is used in the management of concomitant diseases and complications caused by deterioration of liver detoxification function with symptoms of latent or severe hepatic encephalopathy and consciousness disorders such as precoma or coma.
Q: How does HEPAMERZ GRANULES work?
A: L-ornithine converts toxic ammonia into non-toxic urea, which is eliminated via kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-aspartate is an important component of the citric acid cycle, which liberates energy in the form of ATP, which helps in the regeneration of damaged liver cells.
Q: What are the side effects of HEPAMERZ GRANULES?
A: HEPAMERZ GRANULES is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.
Q: Who should avoid taking HEPAMERZ GRANULES?
A: Do not take HEPAMERZ GRANULES if you suffer from renal insufficiency (severely impaired kidney function) or are allergic (hypersensitive) to l-ornithine-l-aspartate. Consult your doctor for advice.
Q: What precautions must be taken while using HEPAMERZ GRANULES?
A: HEPAMERZ GRANULES should be taken with caution in patients with severe liver disease. Consult your doctor for advice. Dose adjustments must be made on an individual basis to avoid nausea and vomiting.
Q: Can I take other medicines along with HEPAMERZ GRANULES?
A: Tell your doctor about all the medicines you use, including prescription and non-prescription medicines and herbal supplements.
Q: What is the best time to take HEPAMERZ GRANULES?
A: Take HEPAMERZ GRANULES after meals or as advised by your doctor. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition. Continue to take this medicine as long as your doctor tells you to do so to obtain better results.
REFERENCES
1. James M. Ritter, Lionel D. Lewis, Timothy GK Mant, and Albert Ferro. The Alimentary system. Alimentary system and liver. A Textbook of Clinical Pharmacology and Therapeutics. Fifth edition. Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK 2008. Page 260-264.
2. Imperial College London. Brain Muscle Axis During Management of Hepatic Encephalopathy With L-ornithine L-aspartate. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in October 2015] [Accessed on 29th August 2024] https://clinicaltrials.gov/ct2/show/NCT01847651
3. Gerald Kircheis and Stefan Lüth. Pharmacokinetic and Pharmacodynamic Properties of L-Ornithine L-Aspartate (LOLA) in Hepatic Encephalopathy. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2019. [Accessed on 29th August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/
4. Ee Teng Goh, Caroline S Stokes, Sandeep S Sidhu, Hendrik Vilstrup, Lise Lotte Gluud, and Marsha Y Morgan. L-ornithine L-aspartate for prevention and management of hepatic encephalopathy in people with cirrhosis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2018. [Accessed on 29th August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494563/
5. Brooks Pharma Pvt. Ltd. Brooks.com.pk. [Accessed on 29th August 2024] https://www.brookes.com.pk/wp-content/uploads/Hepa-Merz.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count (CBC)/ Hemogram
- Urine Routine & Microscopy
- Serum Electrolytes/ Electrolytes Profile
- Liver Function Test (LFT)
- Hepatitis Panel
- Hepatitis B Profile
- Hepatitis C Antibody (Hcvab) Rapid Test
- Hepatitis B Virus (Qualitative)
- Hepatitis E Virus Antibody Igm (Hevm) Rapid Test
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