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Quality Checked ProductsHEPAMERZ contains l-ornithine-l-aspartate which belongs to the group of medicines called hepatoprotective agent. It is used in the management of concomitant diseases and complications caused by deterioration of liver detoxification function, with symptoms of latent or severe hepatic encephalopathy and consciousness disorders such as precoma or coma.
L-ornithine-l-aspartate is made up of two amino acids called ornithine and aspartic acid. Both l-ornithine and l-aspartic acid, ensures hepatoprotective effect by decreasing the toxic load on liver, and by providing metabolic support for hepatic cells. Before taking this medicine, inform your doctor if you have severe liver disease, because your doctor might adjust the dose on an individual basis to avoid nausea and vomiting.
This medicine is well tolerated with minimal side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor. Do not take this medicine if you have severe renal impairment, diabetes or fructose intolerance. Ask your doctor for advice. If high dose of this medicine is used, it is important to monitor the levels of urea both in the serum and urine to avoid toxicity. Ask your doctor for advice before taking this medicine, if you are pregnant or breastfeeding.
L-ornithine converts the toxic ammonia into non-toxic urea which is eliminated via kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-Aspartate is an important component of citric acid cycle which liberates energy in the form of ATP, which helps in regeneration of damaged liver cells.
Always take this medicine as directed by your physician. Dissolve the contents of 1-2 sachets in a large amount of fluid (e.g. in a glass of water or juice) and consume orally, 3 times a day during or after meals. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
HEPAMERZ is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.
HEPAMERZ should be used with caution in pregnant women. Consult your doctor before taking this medicine.
HEPAMERZ should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.
Do not drive or operate any machines if your ability is affected by this medicine.
Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.
Do not take HEPAMERZ, if you suffer from renal insufficiency (severely impaired kidney function). Consult your doctor for advice.
HEPAMERZ should be taken with caution in patients with severe liver disease. Consult your doctor for advice. Dose adjustments has to be made on individual basis to avoid nausea and vomiting.
Do not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.
Tell your doctor about all the medicines you use, including prescription and non-prescription medicines, and herbal supplements.
| Drug | : | L-ornithine-L-aspartate |
| Pharmacological Category | : | Hepatoprotective agent |
| Therapeutic Indication | : | Liver Disease, Hepatic Encephalopathy, Hyperammonemia |
| Dosage Forms | : | Tablet, Granules, Infusion, Syrup |
Store below 20-25°C and keep out of reach of children.
Can we mix HEPAMERZ with juice and consume?
Yes. You can mix the contents of the sachet in a glass of water or juice, and consume orally, 3 times a day during or after meals.
Can HEPAMERZ be taken by pregnant women?
This medicine should be used with caution in pregnant women. Consult your doctor before taking.
Can we consume alcohol while taking HEPAMERZ?
No. Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.
1. James M. Ritter, Lionel D. Lewis, Timothy GK Mant & Albert Ferro. The Alimentary system. Alimentary system and liver. A Textbook of Clinical Pharmacology and Therapeutics. Fifth edition. Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK 2008. Page 260-264.
2. Imperial College London. Brain Muscle Axis During Management of Hepatic Encephalopathy With L-ornithine L-aspartate. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on October 2015] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT01847651
3. Gerald Kircheis and Stefan Lüth. Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2019. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/
4. Ee Teng Goh, Caroline S Stokes, Sandeep S Sidhu, Hendrik Vilstrup, Lise Lotte Gluud and Marsha Y Morgan. L-ornithine L-aspartate for prevention and management of hepatic encephalopathy in people with cirrhosis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2018. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494563/
5. Brooks Pharma Pvt. Ltd. Brooks.com.pk. [Accessed 25th November 2020] https://www.brookes.com.pk/wp-content/uploads/Hepa-Merz.pdf
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