Uses of Domperidone

Domperidone is used in the prevention of nausea and vomiting associated with central or local origin, chemotherapy or radiotherapy, drugs or migraine. It helps to relives Postprandial symptoms of fullness, nausea, epigastric bloating and belching (burping) that is occasionally accompanied by stomach discomfort and heartburn.

Therapeutic Category

Domperidone: Dopamine antagonists

How Domperidone works

Domperidone has an anti-emetic property which acts by blocking a chemical messenger in the brain called dopamine, that transfers information through nerve endings.

Domperidone functions by inhibiting the muscle contraction that occurs naturally in the digestive system and enhances the peristaltic movement in the food pipe which helps in facilitating the digestion time faster, this causes calming down effect, thereby relieving nausea or vomiting sensation. 

Common side effects of Domperidone

  • dry mouth

When to consult your doctor

Consult your doctor:

  • If you experience severe allergic reaction having symptoms such as swelling of the hands, feet, ankle, face, lips and throat which may cause difficulty in swallowing or breathing
  • If you experience any itchy lumpy rash (hives), nettle rash (urticaria)
  • If you experience any uncontrolled movements, which include irregular movements of eyes, an unusual move the of the tongue, abnormal posture (Ex. twisted neck, trembling and muscle stiffness)
  • Have a fast unusual heartbeat
  • Seizures (fits)
  • In case of accidental overdose or ingestion 

Health Tips for Domperidone

  • Take Domperidone exactly as prescribed by your Doctor. Do not alter the dosage or stop taking the medication without consulting your doctor
  • It is usually recommended to take it 15 to 30 minutes before meals. This helps it to work more effectively
  • Alcohol and grapefruit can interact with Domperidone and may increase the risk of side effects or affect its efficacy. It's best to avoid consuming alcohol and grapefruit while taking this medication
  • Let your doctor know if you are pregnant or planning for pregnancy